Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas
PURPOSE: Glioblastoma multiforme (GBM) is the most common primary brain tumor in
adults, and radiation is one of the main treatment modalities. However, cure rates remain low …
adults, and radiation is one of the main treatment modalities. However, cure rates remain low …
Mechanisms of immunotherapy resistance: lessons from glioblastoma
CM Jackson, J Choi, M Lim - Nature immunology, 2019 - nature.com
Glioblastoma (GBM) is the deadliest form of brain cancer, with a median survival of less than
2 years despite surgical resection, radiation, and chemotherapy. GBM’s rapid progression, …
2 years despite surgical resection, radiation, and chemotherapy. GBM’s rapid progression, …
Anti–PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM
…, J Phallen, CK Park, CM Jackson… - Science translational …, 2016 - science.org
The immunosuppressive effects of chemotherapy present a challenge for designing effective
cancer immunotherapy strategies. We hypothesized that although systemic chemotherapy (…
cancer immunotherapy strategies. We hypothesized that although systemic chemotherapy (…
Trigeminal neuralgia: current approaches and emerging interventions
Trigeminal neuralgia (TN) has been described in the literature as one of the most debilitating
presentations of orofacial pain. This review summarizes over 150 years of collective clinical …
presentations of orofacial pain. This review summarizes over 150 years of collective clinical …
Clinical trials investigating immune checkpoint blockade in glioblastoma
R Maxwell, CM Jackson, M Lim - Current treatment options in oncology, 2017 - Springer
Opinion statement Immune checkpoint inhibitors have changed the landscape of cancer
immunotherapy and are being integrated into the standard of care for a variety of solid and …
immunotherapy and are being integrated into the standard of care for a variety of solid and …
[HTML][HTML] STAT3 activation in glioblastoma: biochemical and therapeutic implications
Signal transducer and activator of transcription 3 (STAT3) is a potent regulator of gliomagenesis
through its induction of angiogenesis, host immunosuppression, and tumor invasion. …
through its induction of angiogenesis, host immunosuppression, and tumor invasion. …
Combination anti-CXCR4 and anti-PD-1 immunotherapy provides survival benefit in glioblastoma through immune cell modulation of tumor microenvironment
…, AS Luksik, T Garzon-Muvdi, CM Jackson… - Journal of neuro …, 2019 - Springer
Background Emerging evidence suggests that myeloid cells play a critical role in glioblastoma
(GBM) immunosuppression. Disappointing results of recent checkpoint inhibitor trials …
(GBM) immunosuppression. Disappointing results of recent checkpoint inhibitor trials …
[HTML][HTML] The translational potential of microglia and monocyte-derived macrophages in ischemic stroke
The immune response to ischemic stroke is an area of study that is at the forefront of stroke
research and presents promising new avenues for treatment development. Upon cerebral …
research and presents promising new avenues for treatment development. Upon cerebral …
[HTML][HTML] Sequencing CTLA-4 blockade with cell-based immunotherapy for prostate cancer
S Wada, CM Jackson, K Yoshimura, HR Yen… - Journal of translational …, 2013 - Springer
Background The FDA recently approved an anti-CTLA-4 antibody (Iplimumab) for the
treatment of metastatic melanoma. This decision was based on Phase III results, which …
treatment of metastatic melanoma. This decision was based on Phase III results, which …
Systemic tolerance mediated by melanoma brain tumors is reversible by radiotherapy and vaccination
CM Jackson, CM Kochel, CJ Nirschl, NM Durham… - Clinical Cancer …, 2016 - AACR
Purpose: Immune responses to antigens originating in the central nervous system (CNS)
are generally attenuated, as collateral damage can have devastating consequences. The …
are generally attenuated, as collateral damage can have devastating consequences. The …