User profiles for J. Manley

James L. Manley

- Verified email at columbia.edu - Cited by 57375

Julie Manley

- Verified email at GuidingGreen.com - Cited by 3996

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

M Chen, JL Manley - Nature reviews Molecular cell biology, 2009 - nature.com
… Shi and Manley 151 elucidated the detailed regulatory mechanism of SRp38 phosphorylation
in response to heat shock. Specifically, at normal temperatures two mechanisms ensure …

Mechanism and regulation of mRNA polyadenylation

DF Colgan, JL Manley - Genes & development, 1997 - genesdev.cshlp.org
A poly (A) tail is found at the 3 end of nearly every fully processed eukaryotic mRNA and
has been suggested to influence virtually all aspects of mRNA metabolism. Its proposed …

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

CJ David, JL Manley - Genes & development, 2010 - genesdev.cshlp.org
Alternative splicing of mRNA precursors is a nearly ubiquitous and extremely flexible point
of gene control in humans. It provides cells with the opportunity to create protein isoforms of …

Key green chemistry research areas—a perspective from pharmaceutical manufacturers

…, JL Leazer Jr, RJ Linderman, K Lorenz, J Manley… - Green …, 2007 - pubs.rsc.org
In 2005, the ACS Green Chemistry Institute (GCI) and the global pharmaceutical corporations
developed the ACS GCI Pharmaceutical Roundtable to encourage the integration of green …

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

CJ David, M Chen, M Assanah, P Canoll, JL Manley - Nature, 2010 - nature.com
When oxygen is abundant, quiescent cells efficiently extract energy from glucose primarily
by oxidative phosphorylation, whereas under the same conditions tumour cells consume …

Some general properties of nonlinear elements-Part I. General energy relations

JM Manley, HE Rowe - Proceedings of the IRE, 1956 - ieeexplore.ieee.org
… GENERAL ENERGY RELATIONS IN NONLINEAR REACTORS In this section we derive
JM Manley's power relations for hysteresisless nonlinear capacitors and inductors,'0 which …

SR proteins and splicing control 1569

JL Manley, R Tacke, BLM Hogan, KL Friedman… - Genes …, 1996 - genesdev.cshlp.org
J. Cuddihy (Cold Spring Harbor) … Manley and Roland Tacke … Ferguson, Sarah VM
Nyland, Bonita J. Brewer, and Walton L. Fangman …

The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.

…, T Pawson, B Andrews, J Prasad, JL Manley… - The EMBO …, 1996 - embopress.org
Mammalian Clk/Sty is the prototype for a family of dual specificity kinases (termed LAMMER
kinases) that have been conserved in evolution, but whose physiological substrates are …

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

Y Xu, X Tao, B Shen, T Horng, R Medzhitov, JL Manley… - Nature, 2000 - nature.com
Toll-like receptors (TLRs) and the interleukin-1 receptor superfamily (IL-1Rs) are integral to
both innate and adaptive immunity for host defence 1 , 2 , 3 . These receptors share a …

Alternative polyadenylation of mRNA precursors

B Tian, JL Manley - Nature reviews Molecular cell biology, 2017 - nature.com
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …