Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches
… Shi and Manley 151 elucidated the detailed regulatory mechanism of SRp38 phosphorylation
in response to heat shock. Specifically, at normal temperatures two mechanisms ensure …
in response to heat shock. Specifically, at normal temperatures two mechanisms ensure …
Mechanism and regulation of mRNA polyadenylation
DF Colgan, JL Manley - Genes & development, 1997 - genesdev.cshlp.org
A poly (A) tail is found at the 3 end of nearly every fully processed eukaryotic mRNA and
has been suggested to influence virtually all aspects of mRNA metabolism. Its proposed …
has been suggested to influence virtually all aspects of mRNA metabolism. Its proposed …
Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged
Alternative splicing of mRNA precursors is a nearly ubiquitous and extremely flexible point
of gene control in humans. It provides cells with the opportunity to create protein isoforms of …
of gene control in humans. It provides cells with the opportunity to create protein isoforms of …
Key green chemistry research areas—a perspective from pharmaceutical manufacturers
…, JL Leazer Jr, RJ Linderman, K Lorenz, J Manley… - Green …, 2007 - pubs.rsc.org
In 2005, the ACS Green Chemistry Institute (GCI) and the global pharmaceutical corporations
developed the ACS GCI Pharmaceutical Roundtable to encourage the integration of green …
developed the ACS GCI Pharmaceutical Roundtable to encourage the integration of green …
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
When oxygen is abundant, quiescent cells efficiently extract energy from glucose primarily
by oxidative phosphorylation, whereas under the same conditions tumour cells consume …
by oxidative phosphorylation, whereas under the same conditions tumour cells consume …
Some general properties of nonlinear elements-Part I. General energy relations
JM Manley, HE Rowe - Proceedings of the IRE, 1956 - ieeexplore.ieee.org
… GENERAL ENERGY RELATIONS IN NONLINEAR REACTORS In this section we derive
JM Manley's power relations for hysteresisless nonlinear capacitors and inductors,'0 which …
JM Manley's power relations for hysteresisless nonlinear capacitors and inductors,'0 which …
SR proteins and splicing control 1569
… J. Cuddihy (Cold Spring Harbor) … Manley and Roland Tacke … Ferguson, Sarah VM
Nyland, Bonita J. Brewer, and Walton L. Fangman …
Nyland, Bonita J. Brewer, and Walton L. Fangman …
The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.
Mammalian Clk/Sty is the prototype for a family of dual specificity kinases (termed LAMMER
kinases) that have been conserved in evolution, but whose physiological substrates are …
kinases) that have been conserved in evolution, but whose physiological substrates are …
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
Y Xu, X Tao, B Shen, T Horng, R Medzhitov, JL Manley… - Nature, 2000 - nature.com
Toll-like receptors (TLRs) and the interleukin-1 receptor superfamily (IL-1Rs) are integral to
both innate and adaptive immunity for host defence 1 , 2 , 3 . These receptors share a …
both innate and adaptive immunity for host defence 1 , 2 , 3 . These receptors share a …
Alternative polyadenylation of mRNA precursors
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …