Hypocretin (Hcrt or orexin) somas are located in the hypothalamus and project widely to
forebrain and brainstem regions, densely innervating monoaminergic and cholinergic cells. …

Noradrenergic, serotonergic, and histaminergic neurons are continuously active during
waking, reduce discharge during NREM sleep, and cease discharge during REM sleep. …

Hypocretins (orexins) are recently discovered hypothalamic neuropeptides that have been
implicated in the etiology of narcolepsy. The normal behavioral functions of these peptides …

Objective To determine whether histamine cells are altered in human narcolepsy with
cataplexy and in animal models of this disease. Methods Immunohistochemistry for histidine …

The changes in brain function that perpetuate opiate addiction are unclear. In our studies of
human narcolepsy, a disease caused by loss of immunohistochemically detected hypocretin …

Recent work has implicated the hypocretin (orexin) system in the genesis of narcolepsy. In
the current study we demonstrate that systemically administered hypocretin-1 (Hcrt-1) …

This study was undertaken to determine the effects of the destruction of the medial preoptic
area (mPOA) neu-rons by N-methyl D-aspartic acid (NMDA), on sleep-wakefulness (SW), …

The role of the preoptic area (POA) neurons in the regulation of sleep-wakefulness (S—W)
has been investigated in this study. The cell—specific neurotoxin, kainic acid (KA), was …

The histamine-containing posterior hypothalamic region (PH-TMN) plays a key role in sleep-wake
regulation. We investigated rapid changes in glutamate release in the PH-TMN across …

High-grade serous ovarian carcinoma (HGSOC), the deadliest form of ovarian cancer, is
typically diagnosed after it has metastasized and often relapses after standard-of-care platinum-…