Alzheimer’s disease (AD) is a disease caused by the complex interaction of multiple mechanisms,
some of which are still not fully understood. To date, pharmacological treatments and …

Nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine‐enzyme, which was
described as to play bioactivities both in the intracellular and in the extracellular environment. …

Background Bortezomib-based induction followed by high-dose melphalan (200 mg/m 2 )
and autologous stem-cell transplantation (MEL200-ASCT) and maintenance treatment with …

Approximately 75% of all breast cancers express the oestrogen and/or progesterone receptors.
Endocrine therapy is usually effective in these hormone-receptor-positive tumours, but …

B-cell maturation antigen (BCMA), highly expressed on malignant plasma cells in human
multiple myeloma (MM), has not been effectively targeted with therapeutic monoclonal …

Here we show that overexpression or activation of B-cell maturation antigen (BCMA) by its
ligand, a proliferation-inducing ligand (APRIL), promotes human multiple myeloma (MM) …

Autophagy is a cell recycling process the molecular apparatus of which has been identified
over the past decade. Autophagy allows cells to survive starvation and inhospitable …

Nicotinamide phosphoribosyltransferase (Nampt) inhibitors such as FK866 are potent
inhibitors of NAD + synthesis that show promise for the treatment of different forms of cancer. …

Bruton tyrosine kinase (Btk) has a well-defined role in B-cell development, whereas its
expression in osteoclasts (OCs) further suggests a role in osteoclastogenesis. Here we …

Cytokine secretion by cancer cells contributes to cancer-induced symptoms and angiogenesis.
Studies show that the sirtuin SIRT6 promotes inflammation by enhancing TNF expression…