Most of the current methods for programmable RNA drug therapies are unsuitable for the clinic
due to low uptake efficiency and high cytotoxicity. Extracellular vesicles (EVs) could solve …

The p53 transcription factor is a key tumor suppressor and a central regulator of the stress
response. To ensure a robust and precise response to cellular signals, p53 gene expression …

Background & Aims Magnetic resonance elastography (MRE) and transient elastography (TE)
are noninvasive techniques for detection of liver fibrosis. Single-center studies have …

Diabetic retinopathy is a leading cause of adult vision loss and blindness. Much of the
retinal damage that characterizes the disease results from retinal vascular leakage and …

Background The antiviral efficacy of remdesivir against SARS-CoV-2 is still controversial.
We aimed to evaluate the clinical efficacy of remdesivir plus standard of care compared with …

Background Dengue shock syndrome is characterized by severe vascular leakage and
disordered hemostasis and progresses to death in 1 to 5 percent of cases. Although volume …

The direct reduction of CO 2 to CH 3 OH is known to occur at several types of electrocatalysts
including oxidized Cu electrodes. In this work, we examine the yield behavior of an …

Metastasis is associated with poor prognosis in breast cancer patients. Not all cancer cells
within a tumor are capable of metastasizing. The microRNA-200 (miR-200) family, which …

Turtles and tortoises (chelonians) have been integral components of global ecosystems for
about 220 million years and have played important roles in human culture for at least …

This paper presents an efficiency analysis, accounting for both energy and exergy
considerations, of a design for a cogeneration-based district energy system. A case study is …