The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies
and recombinant proteins, poses substantial challenges owing to their large size and …

Although numerous protein therapeutics have been approved or are in advanced clinical
testing, the development of more sophisticated delivery systems for this rapidly expanding …

Despite recent progress, systemic delivery remains the major hurdle for development of safe
and effective small inhibitory RNA (siRNA)–based therapeutics. Encapsulation of siRNA …

Effective small interfering RNA (siRNA)–mediated therapeutics require the siRNA to be delivered
into the cellular RNA-induced silencing complex (RISC). Quantitative information of this …

Lipid nanoparticles are self-assembling, dynamic structures commonly used as carriers of
siRNA, DNA, and small molecular therapeutics. Quantitative analysis of particle characteristics …

A major hurdle for harnessing small interfering RNA (siRNA) for therapeutic application is
an effective and safe delivery of siRNA to target tissues and cells via systemic administration. …

Establishing a permanent human presence on the Moon or Mars requires a secure supply
of oxygen for life support and refueling. The electrolysis of water has attracted significant …

Purpose. The purpose of this work was to evaluate spray-freeze drying and spray drying
processes for encapsulation of darbepoetin alfa (NESP, Aranesp®). Methods. Darbepoetin alfa …

Purpose. To evaluate spray-freeze drying and spray drying processes for fabricating micron-sized
particles of darbepoetin alfa (NESP, Aranesp®) with uniform size distribution and …

By using solid-state NMR spectroscopy, the integrity of the active center of alpha-chymotrypsin
was investigated under a variety of nonaqueous conditions. Specifically, 13C cross-…