The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
Metabolism and ageing are intimately linked. Compared with ad libitum feeding, dietary
restriction consistently extends lifespan and delays age-related diseases in evolutionarily …
restriction consistently extends lifespan and delays age-related diseases in evolutionarily …
[HTML][HTML] Regulation of the O-linked β-N-acetylglucosamine transferase by insulin signaling
O-Linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) catalyzes the addition of O-linked
β-N-acetylglucosamine (O-GlcNAc) onto serine and threonine residues in response to …
β-N-acetylglucosamine (O-GlcNAc) onto serine and threonine residues in response to …
O-GlcNAc: a regulatory post-translational modification
β-N-Acetylglucosamine (O-GlcNAc) is a regulatory post-translational modification of nuclear
and cytosolic proteins. The enzymes for its addition and removal have recently been cloned …
and cytosolic proteins. The enzymes for its addition and removal have recently been cloned …
[HTML][HTML] Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-linked β-N-acetylglucosamine in 3T3-L1 adipocytes
Increased O-linked β-N-acetylglucosamine (O-GlcNAc) is associated with insulin resistance
in muscle and adipocytes. Upon insulin treatment of insulin-responsive adipocytes, O-…
in muscle and adipocytes. Upon insulin treatment of insulin-responsive adipocytes, O-…
[HTML][HTML] Biosynthetic machinery involved in aberrant glycosylation: promising targets for developing of drugs against cancer
…, MC Lucena, NR Mantuano, SA Whelan… - Frontiers in …, 2015 - frontiersin.org
Cancer cells depend on altered metabolism and nutrient uptake to generate and keep the
malignant phenotype. The hexosamine biosynthetic pathway is a branch of glucose …
malignant phenotype. The hexosamine biosynthetic pathway is a branch of glucose …
[HTML][HTML] Epithelial mesenchymal transition induces aberrant glycosylation through hexosamine biosynthetic pathway activation
Deregulated cellular metabolism is a hallmark of tumors. Cancer cells increase glucose and
glutamine flux to provide energy needs and macromolecular synthesis demands. Several …
glutamine flux to provide energy needs and macromolecular synthesis demands. Several …
Proteomic approaches to analyze the dynamic relationships between nucleocytoplasmic protein glycosylation and phosphorylation
O-linked β-N-acetylglucosamine (O-GlcNAc) is both an abundant and dynamic posttranslational
modification similar to phosphorylation that occurs on serine and threonine residues of …
modification similar to phosphorylation that occurs on serine and threonine residues of …
[HTML][HTML] Tryptophan metabolites suppress the Wnt pathway and promote adverse limb events in chronic kidney disease
…, JD Ravid, MH Kamel, SA Whelan… - The Journal of …, 2022 - Am Soc Clin Investig
Chronic kidney disease (CKD) imposes a strong and independent risk for peripheral artery
disease (PAD). While solutes retained in CKD patients (uremic solutes) inflict vascular …
disease (PAD). While solutes retained in CKD patients (uremic solutes) inflict vascular …
Comparative proteomics reveals dysregulated mitochondrial O-GlcNAcylation in diabetic hearts
O-linked β-N-acetylglucosamine (O-GlcNAc), a post-translational modification on serine and
threonine residues of many proteins, plays crucial regulatory roles in diverse biological …
threonine residues of many proteins, plays crucial regulatory roles in diverse biological …
Mass spectrometry (LC-MS/MS) site-mapping of N-glycosylated membrane proteins for breast cancer biomarkers
SA Whelan, M Lu, J He, W Yan, RE Saxton… - Journal of proteome …, 2009 - ACS Publications
Cancer cell membrane proteins are released into the plasma/serum by exterior protein
cleavage, membrane sloughing, cellular secretion or cell lysis, and represent promising …
cleavage, membrane sloughing, cellular secretion or cell lysis, and represent promising …