Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs. Our
understanding of the genesis of this injury and of potential interventions to prevent, limit, or …

White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance
imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small …

Vascular contributions to cognitive impairment and dementia (VCID) are characterized by
the aging neurovascular unit being confronted with and failing to cope with biological insults …

A novel secreted glycoprotein that regulates bone resorption has been identified. The protein,
termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily. In vivo, …

Purpose To assess the frequency and type of oncogenic BRAF mutations in metastatic
melanoma and correlate BRAF status with clinicopathologic features and outcome. Patients and …

Coronaviruses (CoVs) traffic frequently between species resulting in novel disease outbreaks,
most recently exemplified by the newly emerged SARS-CoV-2, the causative agent of …

Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous
disease with multiple contributors to its pathophysiology, including vascular dysfunction…

The nucleoside analog remdesivir (RDV) is a Food and Drug Administration–approved
antiviral for treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the novel viral disease COVID-19. With no approved therapies, this pandemic illustrates the …

Background Shared decision-making (SDM) is a process that respects the rights of patients
to be fully involved in decisions about their care. By evaluating all available healthcare …