2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus
Objective To develop new classification criteria for systemic lupus erythematosus ( SLE )
jointly supported by the European League Against Rheumatism ( EULAR ) and the American …
jointly supported by the European League Against Rheumatism ( EULAR ) and the American …
The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy
… a | T cells recognize and become activated against peptide antigens through ligation of T
cell surface receptors. Two signals are required for T cell activation. Signal 1 is generated by …
cell surface receptors. Two signals are required for T cell activation. Signal 1 is generated by …
[HTML][HTML] Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic
… Treatment with anti-PD-1, anti-programmed death-ligand 1 (anti-PD-L1), or anti-CTLA-4
reinvigorates T cells and allows the adaptive immune system to target tumor cells [13, 14]. …
reinvigorates T cells and allows the adaptive immune system to target tumor cells [13, 14]. …
Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer
… This analysis revealed a CD8+ T cell response … + T cells, and this response was maintained
at Day 44. This rapid induction of T cell reactivity correlated with tumor regression, and this T …
at Day 44. This rapid induction of T cell reactivity correlated with tumor regression, and this T …
[HTML][HTML] Genetic basis for clinical response to CTLA-4 blockade in melanoma
… T-lymphocyte antigen 4 (CTLA-4). Anti–CTLA-4 treatment prolongs overall survival in patients
with melanoma. CTLA-4 blockade activates T … Predicted neoantigens activated T cells from …
with melanoma. CTLA-4 blockade activates T … Predicted neoantigens activated T cells from …
A multiphase level set framework for image segmentation using the Mumford and Shah model
… model without edges based 2-phase segmentation, developed by the authors earlier in T. …
the descent directions by an artificial time t, respectively (with associated initial conditions): …
the descent directions by an artificial time t, respectively (with associated initial conditions): …
[HTML][HTML] PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs
PPARδ was identified as a target of APC through the analysis of global gene expression
profiles in human colorectal cancer (CRC) cells. PPARδ expression was elevated in CRCs and …
profiles in human colorectal cancer (CRC) cells. PPARδ expression was elevated in CRCs and …
[BOOK][B] Templates for the solution of linear systems: building blocks for iterative methods
… [29) RE BANK AND TF CHAN, A composite step bi-conjugate gradient algorithm for
nonsymmetric linear … CHAN, Fourier analysis of relaxed incomplete factorization preconditioners, …
nonsymmetric linear … CHAN, Fourier analysis of relaxed incomplete factorization preconditioners, …
[PDF][PDF] Integrated genomic characterization of papillary thyroid carcinoma
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …
Tumor mutational load predicts survival after immunotherapy across multiple cancer types
… Early reports have suggested that PD-L1 immunohistochemistry, T-cell infiltration levels, T-cell
receptor clonality, gene expression signatures and peripheral blood markers may …
receptor clonality, gene expression signatures and peripheral blood markers may …